The pattern of structural changes induced in bull spermatozoa by oral or injected ethylene dibromide (EDB).

Bulls treated with ethylene dibromide (EDB), either by oral administration of ten doses of 4 mg/kg body weight on alternate days or by a single intraperitoneal injection of 110 -2 mg of this compound into the fluid surrounding each testis, exhibited sperm malformations up to total disintegration of the sperm cells. The malformations appeared in the ejaculates collected about two weeks after the first oral dose or after the injection, and persisted for about one and two months after the last oral dose or the injection, respectively. It appears that ethylene dibromide interferes with the normal processes of spermiogenesis and sperm maturation.